We are developing a proprietary targeted delivery system for chemotherapeutics, peptides and RNAi
Gagomers are lipidated glycosaminoglycan (Gag) particles. These particles are used to encapsulate siRNA molecules. The anionic, non-sulfated and large Gag used, Hyaluronic Acid (HA), is natural to the body, distributed widely throughout connective, epithelial, and neural tissues. HA primary receptors are CD44 and CD168. CD44 is a cell surface glycoprotein involved in cell-cell interactions, cell adhesion, and migration and is expressed in many cells. High affinity forms of CD44 are highly expressed in tumor cells and in inflammation.
Short interfering RNA (siRNA) is a small family of RNA oligonucleotides that work by RNA Interference (RNAi). These oligos use the cellular machinery, in particular the RNA-induced silencing complex (RISC) to degrade specific mRNAs before they can be translated into proteins. As such, if targeted against mRNA of disease related proteins, they can serve as drugs.