We are developing a proprietary uniquely targeted delivery system for chemotherapeutics, peptides and RNAi
Gagomers are lipidated glycosaminoglycan (Gag) particles. These particles are used to encapsulate a wide range of molecules. The anionic, non-sulfated and large Gag used, Hyaluronic Acid (HA), is natural to the body and its primary receptors are CD44 and CD168. CD44 is a cell surface glycoprotein expressed in many cells. High affinity forms of CD44 (CD44v) are highly expressed in tumor cells and in inflammation. Having HA as a shell, the GAGomers are naturally targeted to cancer cells expressing CD44v.
About GAGomer versatility
The GAGomer core technology is amenable to a wide variety of therapeutics. We have shown in several animal models the improved efficacy of the GAGomer technology harboring nucleic acids such as siRNA and even DNA plasmids, soluble and insoluble small molecules. .